Mathematical modeling of microtubule dynamic instability: new insight into the link between GTP-hydrolysis and microtubule aging

DOI10.1051/M2AN/2017025MaRDI QIDQ5381002zbMATH OpenOpenAlexFDO

Authors Ayuna Barlukova, Diana White, Gérard Henry, Stéphane Honoré, F. Hubert

Publication date 7 June 2019

Published in ESAIM: Mathematical Modelling and Numerical Analysis (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1051/m2an/2017025

zbMATH Keywords

population dynamicsmicrotubulesdynamic instabilitymicrotubule aging

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

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(8)

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• Minimal Mechanisms of Microtubule Length Regulation in Living Cells
• Modeling microtubule dynamic instability: microtubule growth, shortening and pause
• Mathematical modeling of effect of microtubule-targeted agents on microtubule dynamic instability
• Spatial pattern formation in microtubule post-translational modifications and the tight localization of motor-driven cargo
• Microtubules (MT) a key target in oncology: mathematical modeling of anti-MT agents on cell migration
• Phase transition analysis of the dynamic instability of microtubules
• Exploring the effect of end-binding proteins and microtubule targeting chemotherapy drugs on microtubule dynamic instability

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