Maximum likelihood estimation for semiparametric transformation models with interval-censored data
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Publication:5384367
DOI10.1093/BIOMET/ASW013zbMATH Open1499.62419arXiv1602.02184OpenAlexW2259439942WikidataQ31106651 ScholiaQ31106651MaRDI QIDQ5384367FDOQ5384367
Donglin Zeng, D. Y. Lin, Lu Mao
Publication date: 24 June 2019
Published in: Biometrika (Search for Journal in Brave)
Abstract: Interval censoring arises frequently in clinical, epidemiological, financial, and sociological studies, where the event or failure of interest is known only to occur within an interval induced by periodic monitoring. We formulate the effects of potentially time-dependent covariates on the interval-censored failure time through a broad class of semiparametric transformation models that encompasses proportional hazards and proportional odds models. We consider nonparametric maximum likelihood estimation for this class of models with an arbitrary number of monitoring times for each subject. We devise an EM-type algorithm that converges stably, even in the presence of time-dependent covariates, and show that the estimators for the regression parameters are consistent, asymptotically normal, and asymptotically efficient with an easily estimated covariance matrix. Finally, we demonstrate the performance of our procedures through extensive simulation studies and application to an HIV/AIDS study conducted in Thailand.
Full work available at URL: https://arxiv.org/abs/1602.02184
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- scientific article; zbMATH DE number 1104320
EM algorithmsemiparametric efficiencynonparametric likelihoodinterval censoringproportional hazardsproportional oddslinear transformation modeltime-dependent covariatecurrent-status data
Nonparametric estimation (62G05) Censored data models (62N01) Applications of statistics to biology and medical sciences; meta analysis (62P10) General biostatistics (92B15)
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