Maximum likelihood estimation for semiparametric transformation models with interval-censored data

DOI10.1093/BIOMET/ASW013MaRDI QIDQ5384367zbMATH OpenOpenAlexWikidataFDO

Authors Donglin Zeng, Lu Mao, D. Y. Lin

Publication date 24 June 2019

Published in Biometrika (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1602.02184, http://europepmc.org/articles/pmc4890294

zbMATH Keywords

current-status dataEM algorithminterval censoringlinear transformation modelnonparametric likelihoodproportional hazardsproportional oddssemiparametric efficiencytime-dependent covariate

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Censored data models (62N01) Applications of statistics to biology and medical sciences; meta analysis (62P10) General biostatistics (92B15)

Abstract: Interval censoring arises frequently in clinical, epidemiological, financial, and sociological studies, where the event or failure of interest is known only to occur within an interval induced by periodic monitoring. We formulate the effects of potentially time-dependent covariates on the interval-censored failure time through a broad class of semiparametric transformation models that encompasses proportional hazards and proportional odds models. We consider nonparametric maximum likelihood estimation for this class of models with an arbitrary number of monitoring times for each subject. We devise an EM-type algorithm that converges stably, even in the presence of time-dependent covariates, and show that the estimators for the regression parameters are consistent, asymptotically normal, and asymptotically efficient with an easily estimated covariance matrix. Finally, we demonstrate the performance of our procedures through extensive simulation studies and application to an HIV/AIDS study conducted in Thailand.

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• scientific article; zbMATH DE number 1104320

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