Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies

DOI10.1093/BIOMET/ASX045MaRDI QIDQ5384540zbMATH OpenOpenAlexWikidataFDO

Authors Odile Stalder, Alex Asher, Liang Liang, Yanyuan Ma, Nilanjan Chatterjee, Raymond J. Carroll

Publication date 24 June 2019

Published in Biometrika (Search for Journal in Brave)

Full work available at URL https://boris.unibe.ch/112606/7/Stalder%20Biometrika%202017_postprint.pdf

zbMATH Keywords

case-control studygene-environment interactiongenetic epidemiologypseudolikelihoodretrospective studysemiparametric method

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cited in

(9)

• Semiparametric inference on the penetrances of rare genetic mutations based on a case-family design
• A semiparametric efficient estimator in case-control studies for gene-environment independent models
• Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor
• Generalized partial linear varying multi-index coefficient model for gene-environment interactions
• \texttt{Polyunphased}: an extension to polytomous outcomes of the unphased package for family-based genetic association analysis
• Unified Analysis of Secondary Traits in Case–Control Association Studies
• Case-Control Inference of Interaction between Genetic and Nongenetic Risk Factors under Assumptions on Their Distribution
• Extension of the SIMLA Package for Generating Pedigrees with Complex Inheritance Patterns: Environmental Covariates, Gene-Gene and Gene-Environment Interaction
• Methods for modeling gene-environment interplay using polygenic risk scores

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