Optimal allocation of gold standard testing under constrained availability: application to assessment of HIV treatment failure

DOI10.1080/01621459.2013.810149zbMATH Open1288.62163arXiv2010.00692OpenAlexW3105420601WikidataQ37658177 ScholiaQ37658177MaRDI QIDQ5406342FDOQ5406342

Authors: Tao Liu, Joseph W. Hogan, Lisa Wang, Shangxuan Zhang, Rami Kantor 

Publication date: 1 April 2014

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Abstract: The World Health Organization (WHO) guidelines for monitoring the effectiveness of HIV treatment in resource-limited settings (RLS) are mostly based on clinical and immunological markers (e.g., CD4 cell counts). Recent research indicates that the guidelines are inadequate and can result in high error rates. Viral load (VL) is considered the "gold standard", yet its widespread use is limited by cost and infrastructure. In this paper, we propose a diagnostic algorithm that uses information from routinely-collected clinical and immunological markers to guide a selective use of VL testing for diagnosing HIV treatment failure, under the assumption that VL testing is available only at a certain portion of patient visits. Our algorithm identifies the patient subpopulation, such that the use of limited VL testing on them minimizes a pre-defined risk (e.g., misdiagnosis error rate). Diagnostic properties of our proposal algorithm are assessed by simulations. For illustration, data from the Miriam Hospital Immunology Clinic (RI, USA) are analyzed.

Full work available at URL: https://arxiv.org/abs/2010.00692

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zbMATH Keywords

constrained optimizationROCHIV/AIDSresource limitedantiretroviral failuretripartite classification

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Testing in survival analysis and censored data (62N03)

Cites Work

• The elements of statistical learning. Data mining, inference, and prediction
• Title not available (Why is that?)
• Asymptotic Statistics
• Title not available (Why is that?)
• Nonparametric and semiparametric estimation of the receiver operating characteristic curve
• Title not available (Why is that?)
• Combining diagnostic test results to increase accuracy
• Measurement Error in Nonlinear Models
• Statistical decision theory and Bayesian analysis. 2nd ed
• Logistic disease incidence models and case-control studies
• Title not available (Why is that?)
• Separate sample logistic discrimination
• Measurement error models.
• Nonparametric standard errors and confidence intervals
• Title not available (Why is that?)
• Multivariate logistic compounds
• Empirical likelihood ratio based confidence intervals for mixture proportions
• Evaluating the Predictiveness of a Continuous Marker
• On errors-in-variables for binary regression models
• Characterizing the relationship between HIV-1 genotype and phenotype: prediction-based classification
• Prediction-based classification for longitudinal biomarkers
• Super Learning: An Application to the Prediction of HIV-1 Drug Resistance

Cited In (1)

• Screening with Cost-Effective Quality Control: Potential Applications to HIV and Drug Testing

Uses Software

• ElemStatLearn

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