Cluster Newton Method for Sampling Multiple Solutions of Underdetermined Inverse Problems: Application to a Parameter Identification Problem in Pharmacokinetics

DOI10.1137/120885462zbMath1290.65062OpenAlexW2004087869MaRDI QIDQ5418039

Akihiko Konagaya, Ken Hayami, Yasunori Aoki, Hans De Sterck

Publication date: 26 May 2014

Published in: SIAM Journal on Scientific Computing (Search for Journal in Brave)

Full work available at URL: https://semanticscholar.org/paper/19bd455e6aca9766b8eaa8f88c1200d59be9acfa

zbMATH Keywords

algorithmmethod of least squaresnumerical examplesinverse problemspharmacokineticsmultiple solutionLevenberg-Marquardt methodleast-squares fittingunderdetermined problemsODE parameter identification

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Inverse problems involving ordinary differential equations (34A55) Numerical solution of inverse problems involving ordinary differential equations (65L09)

Related Items (4)

Cluster Gauss-Newton method. An algorithm for finding multiple approximate minimisers of nonlinear least squares problems with applications to parameter estimation of pharmacokinetic models ⋮ Improvements to the cluster Newton method for underdetermined inverse problems ⋮ Optimization problems for machine learning: a survey ⋮ A derivative-free Gauss-Newton method

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