Pulsatile viscous flows in elliptical vessels and annuli: solution to the inverse problem, with application to blood and cerebrospinal fluid flow

DOI10.1137/120903385zbMATH Open1391.76884DBLPjournals/siamam/BerselliGMS14arXiv1212.6410OpenAlexW2049979469WikidataQ61988380 ScholiaQ61988380MaRDI QIDQ5418052FDOQ5418052

Authors: Luigi C. Berselli, Francesca Guerra, B. Mazzolai, E. Sinibaldi 

Publication date: 26 May 2014

Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Abstract: We consider the fully-developed flow of an incompressible Newtonian fluid in a cylindrical vessel with elliptical cross-section (both an ellipse and the annulus between two confocal ellipses). In particular, we address an inverse problem, namely to compute the velocity field associated with a given, time-periodic flow rate. This is motivated by the fact that flow rate is the main physical quantity which can be actually measured in many practical situations. We propose a novel numerical strategy, which is nonetheless grounded on several analytical relations. The proposed method leads to the solution of some simple ordinary differential systems. It holds promise to be more amenable to implementation than previous approaches, which are substantially based on the challenging computation of Mathieu functions. Some numerical results are reported, based on measured data for human blood flow in the internal carotid artery, and cerebrospinal fluid (CSF) flow in the upper cervical region of the human spine. As expected, computational efficiency is the main asset of our solution: a speed-up factor over 10^3 was obtained, compared to more elaborate numerical approaches. The main goal of the present study is to provide an improved source of initial/boundary data for more ambitious numerical approaches, as well as a benchmark solution for pulsatile flows in elliptical sections with given flow rate. The proposed method can be effectively applied to bio-fluid dynamics investigations (possibly addressing key aspects of relevant diseases), to biomedical applications (including targeted drug delivery and energy harvesting for implantable devices), up to longer-term medical microrobotics applications.

Full work available at URL: https://arxiv.org/abs/1212.6410

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zbMATH Keywords

inverse problemblood flowcerebrospinal fluid flowpulsatile laminar flowelliptical vessel

Mathematics Subject Classification ID

Navier-Stokes equations (35Q30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Inverse problems for PDEs (35R30) Physiological flows (76Z05) Physiological flow (92C35)

Cited In (4)

• Exact solution to the inverse Womersley problem for pulsatile flows in cylindrical vessels, with application to magnetic particle targeting
• Effect of slip boundary conditions on unsteady pulsatile nanofluid flow through a sinusoidal channel: an analytical study
• Analysis of a reduced-order approximate deconvolution model and its interpretation as a Navier-Stokes-Voigt regularization
• Nonreflecting boundary conditions for a CSF model of fourth ventricle: spinal SAS dynamics

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