DYNAMICS AND CODING OF A BIOLOGICALLY-MOTIVATED NETWORK

DOI10.1142/S0218127406014861zbMATH Open1111.37065arXivq-bio/0407031OpenAlexW2140832964MaRDI QIDQ5484864FDOQ5484864

Authors:

Publication date: 21 August 2006

Published in: International Journal of Bifurcation and Chaos in Applied Sciences and Engineering (Search for Journal in Brave)

Abstract: A four-node network consisting of a negative loop controlling a positive one is studied. It models some of the features of the p53 gene network. Using piecewise linear dynamics with thresholds, the allowed dynamical classes are fully characterized and coded. The biologically relevant situations are identified and conclusions drawn concerning the effectiveness of the p53 network as a tumour inhibitor mechanism.

Full work available at URL: https://arxiv.org/abs/q-bio/0407031

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zbMATH Keywords

biological networkscontrollingp53 networkdynamical classestumor inhibitor mechanism

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Dynamical systems in biology (37N25) Neural biology (92C20) Control/observation systems in abstract spaces (93C25)

Cites Work

• Necessary conditions for multistationarity and stable periodicity
• Multistationarity, the basis of cell differentiation and memory. II: Logical analysis of regulatory networks in terms of feedback circuits
• Positive and negative circuits in dynamical systems
• Logical identification of all steady states: The concept of feedback loop characteristic states
• Multistationarity, the basis of cell differentiation and memory. I: Structural conditions of multistationarity and other nontrivial behavior
• Dynamical behaviour of biological regulatory networks. I: Biological role of feedback loops and practical use of the concept of the loop- characteristic state
• TOOLS FOR NETWORK DYNAMICS

Cited In (3)

• Dynamic switching of neural codes in networks with gap junctions
• Title not available (Why is that?)
• Dynamic modularity in discrete-time models of regulatory networks

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