DYNAMICS AND CODING OF A BIOLOGICALLY-MOTIVATED NETWORK

DOI10.1142/S0218127406014861MaRDI QIDQ5484864zbMATHOpenAlexFDO

Authors

Publication date 21 August 2006

Published in International Journal of Bifurcation and Chaos in Applied Sciences and Engineering (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0407031

zbMATH Keywords

biological networkscontrollingp53 networkdynamical classestumor inhibitor mechanism

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Dynamical systems in biology (37N25) Neural biology (92C20) Control/observation systems in abstract spaces (93C25)

Abstract: A four-node network consisting of a negative loop controlling a positive one is studied. It models some of the features of the p53 gene network. Using piecewise linear dynamics with thresholds, the allowed dynamical classes are fully characterized and coded. The biologically relevant situations are identified and conclusions drawn concerning the effectiveness of the p53 network as a tumour inhibitor mechanism.

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Cites work

• Dynamical behaviour of biological regulatory networks. I: Biological role of feedback loops and practical use of the concept of the loop- characteristic state
• Logical identification of all steady states: The concept of feedback loop characteristic states
• Multistationarity, the basis of cell differentiation and memory. I: Structural conditions of multistationarity and other nontrivial behavior
• Multistationarity, the basis of cell differentiation and memory. II: Logical analysis of regulatory networks in terms of feedback circuits
• Necessary conditions for multistationarity and stable periodicity
• Positive and negative circuits in dynamical systems
• TOOLS FOR NETWORK DYNAMICS

Cited in

(3)

• Dynamic switching of neural codes in networks with gap junctions
• Dynamic modularity in discrete-time models of regulatory networks
• scientific article; zbMATH DE number 843063 (Why is no real title available?)

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