Failure time analysis of HIV vaccine effects on viral load and antiretroviral therapy initiation

DOI10.1093/BIOSTATISTICS/KXI014MaRDI QIDQ5694082zbMATH OpenOpenAlexWikidataFDO

Authors Peter B. Gilbert, Yanqin Sun

Publication date 29 September 2005

Published in Biostatistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1093/biostatistics/kxi014

zbMATH Keywords

Gaussian multipliers techniqueHIV vaccine efficacy trialKaplan-Meier estimatorSimultaneous confidence bands

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Nonparametric tolerance and confidence regions (62G15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Recommendations

• Simultaneous inferences of HIV vaccine effects on viral load, CD4 cell counts, and antiretroviral therapy initiation in phase 3 trials
• The 2-sample problem for failure rates depending on a continuous mark: an application to vaccine efficacy
• Viral suppression in HIV studies: combining times to suppression and rebound
• Mark-specific hazard ratio model with multivariate continuous marks: an application to vaccine efficacy
• Incorporating founder virus information in vaccine field trials

Cited in

(7)

• Predicting overall vaccine efficacy in a new setting by re-calibrating baseline covariate and intermediate response endpoint effect modifiers of type-specific vaccine efficacy
• JOINT IMPACTS OF THERAPY DURATION, DRUG EFFICACY AND TIME LAG IN IMMUNE EXPANSION ON IMMUNITY BOOSTING BY ANTIVIRAL THERAPY
• Incorporating founder virus information in vaccine field trials
• Viral suppression in HIV studies: combining times to suppression and rebound
• Simultaneous inferences of HIV vaccine effects on viral load, CD4 cell counts, and antiretroviral therapy initiation in phase 3 trials
• Nonparametric Estimation of the Joint Distribution of a Survival Time Subject to Interval Censoring and a Continuous Mark Variable
• Estimation of semiparametric regression model with longitudinal data

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