Statistical Inference in Evolutionary Models of DNA Sequences via the EM Algorithm

DOI10.2202/1544-6115.1127MaRDI QIDQ5700522zbMATH OpenOpenAlexWikidataFDO

Authors Asger Hobolth, Jens Ledet Jensen

Publication date 28 October 2005

Published in Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL http://www.bepress.com/sagmb/vol4/iss1/art18

Mathematics Subject Classification ID

Markov processes: estimation; hidden Markov models (62M05) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Problems related to evolution (92D15) Protein sequences, DNA sequences (92D20)

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Cited in

(18)

• Fitting and interpreting continuous-time latent Markov models for panel data
• Maximum likelihood estimation and natural pairwise estimating equations are identical for three sequences and a symmetric 2-state substitution model
• Maximum likelihood estimation of symmetric group-based models via numerical algebraic geometry
• The multivariate Wright-Fisher process with mutation: moment-based analysis and inference using a hierarchical beta model
• Using the EM algorithm to estimate parameters in phylogenetic tree reconstruction
• Computational methods for birth-death processes
• Summary Statistics for Endpoint-Conditioned Continuous-Time Markov Chains
• Statistical inference for DNA sequences of promoters: a non-stationary qualitative model
• The jigsaw puzzle of sequence phenotype inference: piecing together Shannon entropy, importance sampling, and empirical Bayes
• Simulation from endpoint-conditioned, continuous-time Markov chains on a finite state space, with applications to molecular evolution
• The EM algorithm and the rise of computational biology
• A novel method and comparison of methods for constructing Markov bridges
• ML, PL, QL in Markov Chain Models
• Generator estimation of Markov jump processes
• Counting labeled transitions in continuous-time Markov models of evolution
• Consistent estimation for discretely observed Markov jump processes with an absorbing state
• scientific article; zbMATH DE number 5221540 (Why is no real title available?)
• Mixed Model Analysis of DNA Sequence Evolution

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