Variance Estimation in Clinical Studies with Interim Sample Size Reestimation

DOI10.1111/j.1541-0420.2005.00315.xzbMath1079.62116OpenAlexW2118549946WikidataQ47375454 ScholiaQ47375454MaRDI QIDQ5714617

Frank Miller

Publication date: 3 January 2006

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2005.00315.x

zbMATH Keywords

variance estimationadaptive designclinical studiesbias of variance estimationbounds for biasinterim sample size reestimation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Estimation in survival analysis and censored data (62N02)

Related Items (3)

Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations ⋮ Practical Methods for Bounding Type I Error Rate with an Internal Pilot Design ⋮ Blinded and unblinded internal pilot study designs for clinical trials with count data

Cites Work

• Sample size re-estimation without unblinding for normally distributed outcomes with unknown variance
• An Improved Double Sampling Procedure Based on the Variance
• A Two-Sample Test for a Linear Hypothesis Whose Power is Independent of the Variance

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