Optimal Bayesian adaptive trials when treatment efficacy depends on biomarkers

DOI10.1111/BIOM.12437MaRDI QIDQ5739265zbMATH OpenOpenAlexWikidataFDO

Authors Yifan Zhang, Lorenzo Trippa, Giovanni Parmigiani

Publication date 15 July 2016

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://biostats.bepress.com/cgi/viewcontent.cgi?article=1192&context=harvardbiostat

zbMATH Keywords

dynamic programmingpersonalized medicineoptimal strategybiomarkersBayesian adaptive designs

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Dynamic programming (90C39)

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Cites work

• scientific article; zbMATH DE number 1965513 (Why is no real title available?)
• Approximate Dynamic Programming
• Decision Theory
• The Randomized Play-the-Winner Rule in Medical Trials
• The Search for Optimality in Clinical Trials

Cited in

(10)

• Designing precision medicine trials to yield a greater population impact
• A signature enrichment design with Bayesian adaptive randomization
• Biomarker-driven adaptive design
• Bayesian adaptive trial design for a continuous biomarker with possibly nonlinear or nonmonotone prognostic or predictive effects
• Bayesian uncertainty directed trial designs
• Frequentist operating characteristics of Bayesian optimal designs via simulation
• Adaptive clinical trial designs to detect interaction between treatment and a dichotomous biomarker
• A subgroup cluster-based Bayesian adaptive design for precision medicine
• Data-adaptive efficient estimation strategies for biomarker studies embedded in randomized trials
• Design of experiments for a confirmatory trial of precision medicine

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