Foliation-Based Parameter Tuning in a Model of the GnRH Pulse and Surge Generator

DOI10.1137/080732237zbMATH Open1193.34096arXiv0809.1722OpenAlexW3102636207MaRDI QIDQ5850849FDOQ5850849

Authors: Alexandre Vidal, Frédérique Clément 

Publication date: 20 January 2010

Published in: SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Abstract: We investigate a model of the GnRH pulse and surge generator, with the definite aim of constraining the model GnRH output with respect to a physiologically relevant list of specifications. The alternating pulse and surge pattern of secretion results from the interaction between a GnRH secreting system and a regulating system exhibiting fast-slow dynamics. The mechanisms underlying the behavior of the model are reminded from the study of the Boundary-Layer System according to the "dissection method" principle. Using singular perturbation theory, we describe the sequence of bifurcations undergone by the regulating (FitzHugh-Nagumo) system, encompassing the rarely investigated case of homoclinic connexion. Basing on pure dynamical considerations, we restrict the space of parameter search for the regulating system and describe a foliation of this restricted space, whose leaves define constant duration ratios between the surge and the pulsatility phase in the whole system. We propose an algorithm to fix the parameter values to also meet the other prescribed ratios dealing with amplitude and frequency features of the secretion signal. We finally apply these results to illustrate the dynamics of GnRH secretion in the ovine species and the rhesus monkey.

Full work available at URL: https://arxiv.org/abs/0809.1722

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zbMATH Keywords

bifurcationscoupled oscillatorsslow-fast dynamicsovulationamplitude and frequency controlGnRH pulsatilityGnRH surge

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Bifurcation theory for ordinary differential equations (34C23) General biology and biomathematics (92B05) Relaxation oscillations for ordinary differential equations (34C26) Multiple scale methods for ordinary differential equations (34E13)

Cited In (8)

• Canard-mediated (de)synchronization in coupled phantom bursters
• Coupled multiple timescale dynamics in populations of endocrine neurons: pulsatile and surge patterns of GnRH secretion
• A multiple time scale coupling of piecewise linear oscillators. Application to a neuroendocrine system
• Mixed-mode oscillations in a piecewise linear system with multiple time scale coupling
• Mathematical Modeling of the GnRH Pulse and Surge Generator
• Symmetric coupling of multiple timescale systems with mixed-mode oscillations and synchronization
• Modelling square-wave pulse regulation
• Canard cycles in global dynamics

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