A Frailty‐Model‐Based Approach to Estimating the Age‐Dependent Penetrance Function of Candidate Genes Using Population‐Based Case‐Control Study Designs: An Application to Data on the BRCA1 Gene

DOI10.1111/j.1541-0420.2008.01184.xzbMath1180.62159OpenAlexW2090615461WikidataQ33408340 ScholiaQ33408340MaRDI QIDQ5850959

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Publication date: 21 January 2010

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2949411

zbMATH Keywords

semiparametric survival analysisnonparametric maximum likelihoodcasebreast cancer dataBRCA1age-dependent penetrance functioncandidate genecontrol study design

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Nonparametric estimation (62G05) Medical applications (general) (92C50) Genetics and epigenetics (92D10)

Related Items (5)

Robust logistic regression of family data in the presence of missing genotypes ⋮ Frailty Models for Familial Risk With Application to Breast Cancer ⋮ On Estimation of the Hazard Function From Population-Based Case–Control Studies ⋮ Missing genetic information in case-control family data with general semi-parametric shared frailty model ⋮ Semiparametric estimation in copula models for bivariate sequential survival times

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• Estimation of Variance in Cox's Regression Model with Shared Gamma Frailties
• Design and Analysis of Two-Phase Studies with Binary Outcome Applied to Wilms Tumour Prognosis
• Logistic regression of family data from case-control studies
• Case–Control and Case‐Only Designs with Genotype and Family History Data: Estimating Relative Risk, Residual Familial Aggregation, and Cumulative Risk

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