RECEPTOR-MEDIATED ENDOCYTOSIS MODELING OF ANTIBODY-DRUG CONJUGATES TO THE RELEASED PAYLOAD WITHIN THE INTRACELLULAR SPACE CONSIDERING TARGET ANTIGEN EXPRESSION LEVELS

DOI10.11948/20190232MaRDI QIDQ5858080zbMATH OpenOpenAlexFDO

Authors Jong Hyuk Byun, Anna Park, Il Hyo Jung

Publication date 9 April 2021

Published in Journal of Applied Analysis & Computation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.11948/20190232

zbMATH Keywords

ADC mathematical modelantibody-drug conjugates (ADCs)bystander-Killing effectdrug deliveryreceptor-mediated endocytosistarget antigen expression level

Mathematics Subject Classification ID

Mathematical modeling or simulation for problems pertaining to biology (92-10) Medical applications (general) (92C50)

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Cites work

• A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback
• scientific article; zbMATH DE number 3127869 (Why is no real title available?)

Cited in

(5)

• Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC
• A mechanistic compartmental model for total antibody uptake in tumors
• Mathematical modeling of the receptor-mediated endocytosis process of targeted therapeutic agents in drug delivery systems
• Development and Validation of a Mathematical Model to Describe Anti-Cancer Prodrug Activation by Antibody-Enzyme Conjugates
• Input-driven memory dynamics via convolution operators

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