On marginal and conditional parameters in logistic regression models

DOI10.1093/BIOMET/ASZ019zbMATH Open1464.62353arXiv1804.03062OpenAlexW2796279334MaRDI QIDQ5859778FDOQ5859778

Elena Stanghellini, Marco Doretti

Publication date: 20 April 2021

Published in: Biometrika (Search for Journal in Brave)

Abstract: A fundamental research question is how much a variation in a covariate influences a binary response variable in a logistic regression model, both directly or through mediators. We derive the exact formula linking the parameters of marginal and conditional regression models with binary mediators when no conditional independence assumptions can be made. The formula has the appealing property of being the sum of terms that vanish whenever parameters of the conditional models vanish, thereby recovering well-known results as particular cases. It also permits to quantify the distortion induced by omission of some relevant covariates, opening the way to sensitivity analysis. Also in this case, as the parameters of the conditional models are multiplied by terms that are always positive or bounded, the formula may be used to construct reasonable bounds on the parameters of interest. We assume that, conditionally on a set of covariates, the data-generating process can be represented by a Directed Acyclic Graph. We also show how the results here presented lead to the extension of path analysis to a system of binary random variables.

Full work available at URL: https://arxiv.org/abs/1804.03062

zbMATH Keywords

mediationsensitivity analysisdirected acyclic graphpath analysisdistortioncollapsibilitymarginal odds ratio

Mathematics Subject Classification ID

Applications of graph theory (05C90) Generalized linear models (logistic models) (62J12)

Cited In (6)

• Marginal log-linear models and mediation analysis
• PATH ANALYSIS WITH LOGISTIC REGRESSION MODELS : EFFECT ANALYSIS OF FULLY RECURSIVE CAUSAL SYSTEMS OF CATEGORICAL VARIABLES
• Mediation analysis with case-control sampling: identification and estimation in the presence of a binary mediator
• Direct effect and indirect effect on an outcome under nonlinear modeling
• Some approximations to the path formula for some nonlinear models
• Exact parametric causal mediation analysis for a binary outcome with a binary mediator

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