Multiscale modelling via split-step methods in neural firing

DOI10.1080/13873954.2018.1488740MaRDI QIDQ5861090zbMATH OpenOpenAlexWikidataFDO

Authors Pavol Bauer, Stefan Engblom, Sanja Mikulovic, Aleksandar Senek

Publication date 4 March 2022

Published in Mathematical and Computer Modelling of Dynamical Systems (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1611.00509

zbMATH Keywords

computational neuroscienceHodgkin-Huxley equationLie-Trotter splittingmultiphysics couplingstochastic simulation

Mathematics Subject Classification ID

Computational methods for problems pertaining to biology (92-08) Neural biology (92C20)

Abstract: Neuronal models based on the Hodgkin-Huxley equation form a fundamental framework in the field of computational neuroscience. While the neuronal state is often modeled deterministically, experimental recordings show stochastic fluctuations, presumably driven by molecular noise from the underlying microphysical conditions. In turn, the firing of individual neurons gives rise to an electric field n extracellular space, also thought to affect the firing pattern of nearby neurons. We develop a multiscale model which combines a stochastic ion channel gating process taking place on the neuronal membrane, together with the propagation of an action potential along the neuronal structure. We also devise a numerical method relying on a split-step strategy which effectively couples these two processes and we experimentally test the feasibility of this approach. We finally also explain how the approach can be extended with Maxwell's equations to allow the potential to be propagated in extracellular space.

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Cites work

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Cited in

(2)

• Stochastic simulation of neurons, axons, and action potentials
• MULTISCALE COMPUTATIONS ON NEURAL NETWORKS: FROM THE INDIVIDUAL NEURON INTERACTIONS TO THE MACROSCOPIC-LEVEL ANALYSIS

Describes a project that uses

Uses Software

• COMSOL
• Rallpacks

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