Predicting an optimal composite outcome variable for Huntington's disease clinical trials

DOI10.1080/02664763.2020.1759034MaRDI QIDQ5861589zbMATH OpenOpenAlexFDO

Authors Daniel K. Sewell, Journey Penney, Melissa Jay, Ying Zhang, Jane S. Paulsen

Publication date 1 March 2022

Published in Journal of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132919

zbMATH Keywords

longitudinal datamixed effects modelsoptimizationsignal-to-noise ratiotranslational science

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

Recommendations

• Penalized nonlinear mixed effects model to identify biomarkers that predict disease progression
• Cox regression with exclusion frequency-based weights to identify neuroimaging markers relevant to Huntington's disease onset
• Dynamic prediction for multiple repeated measures and event time data: an application to Parkinson's disease
• Leveraging nonlinear dynamic models to predict progression of neuroimaging biomarkers
• Predicting disease onset from mutation status using proband and relative data with applications to Huntington's disease

Cited in

(1)

• A NOTE ON ASYMPTOTIC EFFICIENCY OF A REGRESSION COEFFICIENT PARAMETER UNDER ORDINAL LOGISTIC REGRESSION MODEL

Describes a project that uses

Uses Software

• bootstrap

This page was built for publication: Predicting an optimal composite outcome variable for Huntington's disease clinical trials

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5861589)