Uniqueness and numerical inversion in the time-domain fluorescence diffuse optical tomography

DOI10.1088/1361-6420/AC88F3MaRDI QIDQ5867673zbMATH OpenOpenAlexFDO

Authors Chunlong Sun, Zhidong Zhang

Publication date 14 September 2022

Published in Inverse Problems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2112.10077

zbMATH Keywords

numerical inversionuniquenessinverse source problemFDOT

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Numerical computation using splines (65D07) Biomedical imaging and signal processing (92C55) Smoothness and regularity of solutions to PDEs (35B65) Numerical computation of solutions to systems of equations (65H10) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Boltzmann equations (35Q20) PDEs in connection with optics and electromagnetic theory (35Q60) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Ill-posed problems for PDEs (35R25) Inverse problems for PDEs (35R30) Laplace transform (44A10) Numerical solutions of ill-posed problems in abstract spaces; regularization (65J20) Numerical methods for ill-posed problems for initial value and initial-boundary value problems involving PDEs (65M30) Numerical methods for inverse problems for initial value and initial-boundary value problems involving PDEs (65M32) Inverse problems (including inverse scattering) in optics and electromagnetic theory (78A46) PDE constrained optimization (numerical aspects) (49M41)

Abstract: This work considers the time-domain fluorescence diffuse optical tomography (FDOT). We recover the distribution of fluorophores in biological tissue by the boundary measurements. With the Laplace transform and the knowledge of complex analysis, we build the uniqueness theorem of this inverse problem. After that, the numerical reconstructions are considered. We introduce a non-iterative inversion strategy by peak detection and an iterative inversion algorithm under the framework of regularizing scheme, then give several numerical examples in three-dimensional space illustrating the performance of the proposed inversion schemes.

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Cited in

(6)

• A hybrid inverse problem in the fluorescence ultrasound modulated optical tomography in the diffusive regime
• On uniqueness in diffuse optical tomography
• On forward and inverse models in fluorescence diffuse optical tomography
• Approximate peak time and its application to time-domain fluorescence diffuse optical tomography
• The direct Robin boundary value parabolic system of time-resolved diffuse optical tomography with fluorescence
• Convergence estimates of the Tikhonov-type regularized solutions for the time-domain fluorescence diffuse optical tomography

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