Stochastic optimal control of pre-exposure prophylaxis for HIV infection

DOI10.1093/IMAMMB/DQAC003MaRDI QIDQ5867690zbMATH OpenOpenAlexWikidataFDO

Authors Jasmina Djordjević, Kristina Rognlien Dahl

Publication date 14 September 2022

Published in Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2009.03594

zbMATH Keywords

constrained control problemHIVnumerical examplespre-exposure prophylaxisstochastic differential equationsstochastic optimal controlunconstrained control problem

Mathematics Subject Classification ID

Applications of stochastic analysis (to PDEs, etc.) (60H30) Medical applications (general) (92C50) Optimal stochastic control (93E20)

Abstract: In this paper, we study the stochastic optimal control problem for the PReP vaccine in the stochastic model for HIV/AIDS with PReP. By using the stochastic maximum principle, we derive the stochastic optimal control of PReP for the unconstrained control problem, as well as for two different types of budget constrains. We illustrate the results by a numerical example. We first study the PReP stochastic differential equation dynamics with a constant, deterministic PReP treatment rate. Then, we compare this to the stochastic optimal control in the unconstrained case.

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Cited in

(9)

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• Modelling and optimal control of HIV/AIDS prevention through PrEP and limited treatment
• MAXIMUM PRINCIPLE FOR AGE AND DURATION STRUCTURED SYSTEMS: A TOOL FOR OPTIMAL PREVENTION AND TREATMENT OF HIV
• Numerical optimal control for HIV prevention with dynamic budget allocation
• Needle exchange for controlling HIV spread under endogenous infectivity
• Stochastic optimal control of pre-exposure prophylaxis for HIV infection for a jump model
• Volterra-type integral model for epidemic of COVID-19
• Optimal control of a stochastic SVIR model with logistic growth and saturated incidence function

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