Separable Effects for Causal Inference in the Presence of Competing Events
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Abstract: In time-to-event settings, the presence of competing events complicates the definition of causal effects. Here we propose the new separable effects to study the causal effect of a treatment on an event of interest. The separable direct effect is the treatment effect on the event of interest not mediated by its effect on the competing event. The separable indirect effect is the treatment effect on the event of interest only through its effect on the competing event. Similar to Robins and Richardson's extended graphical approach for mediation analysis, the separable effects can only be identified under the assumption that the treatment can be decomposed into two distinct components that exert their effects through distinct causal pathways. Unlike existing definitions of causal effects in the presence of competing events, our estimands do not require cross-world contrasts or hypothetical interventions to prevent death. As an illustration, we apply our approach to a randomized clinical trial on estrogen therapy in individuals with prostate cancer.
Recommendations
- Estimation of separable direct and indirect effects in continuous time
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- Causal mediation of semicompeting risks
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- Discussion on “Causal mediation of semicompeting risks” by Yen‐Tsung Huang
Cites work
- A new approach to causal inference in mortality studies with a sustained exposure period—application to control of the healthy worker survivor effect
- Analysing Competing Risks Data With Transformation Models
- Defining causal mediation with a longitudinal mediator and a survival outcome
- Principal stratification in causal inference
- The Analysis of Failure Times in the Presence of Competing Risks
Cited in
(35)- Discussion on “Causal mediation of semicompeting risks” by Yen‐Tsung Huang
- Discussion on “Causal mediation of semicompeting risks” by Yen‐Tsung Huang
- Estimation of separable direct and indirect effects in continuous time
- Unified semicompeting risks analysis of hepatitis natural history through mediation modeling
- Conditional Separable Effects
- Estimation of separable direct and indirect effects in a continuous-time illness-death model
- Resampling-based confidence intervals and bands for the average treatment effect in observational studies with competing risks
- The survival-incorporated median vs the median in the survivors or in the always-survivors: what are we measuring? And why?
- Multistate models as a framework for estimand specification in clinical trials of complex processes
- Ranking of average treatment effects with generalized random forests for time-to-event outcomes
- Exploring causal mechanisms and quantifying direct and indirect effects using a joint modeling approach for recurrent and terminal events
- Using principal stratification in analysis of clinical trials
- Doubly robust estimation of the hazard difference for competing risks data
- Asymptotic properties of resampling-based processes for the average treatment effect in observational studies with competing risks
- Separable and controlled direct effects for competing events: estimation of component specific effects on sickness absence
- Inference about separable causal effects with longitudinal bivariate ordinal responses with missingness and censoring
- Survival analysis under the Aalen's additive hazards model with covariate measurement error: application to causal mediation analysis
- A class of directed acyclic graphs with mixed data types in mediation analysis
- Separable effects of semicompeting risks: the effects of hepatitis B on liver cancer via liver cirrhosis
- A positivity robust strategy to study effects of switching treatment
- The subtype-free average causal effect for heterogeneous disease etiology
- Exploring causal effects of hormone- and radio-treatments in an observational study of breast cancer using copula-based semi-competing risks models
- Survivor average causal effects for continuous time: a principal stratification approach to causal inference with semicompeting risks
- Inverse probability of treatment weighting using the propensity score with competing risks in survival analysis
- Measurement error correction in mediation analysis under the additive hazards model
- Matching methods for truncation by death problems
- Nonparametric path-specific effects on a survival outcome through multiple time-to-event mediators
- Time-dependent mediators in survival analysis: graphical representation of causal assumptions
- Censoring, competing events, and multistate models: Comment on: ``Hazards constitute key quantities for analyzing, interpreting and understanding time-to-event data
- Targeted maximum likelihood estimation for mediation analysis with multiple time-varying mediators
- Causal effect on the number of life years lost due to a specific event: average treatment effect and variable importance
- Proximal causal inference for conditional separable effects
- Hypothesis tests of direct and indirect effects under various semicompeting risks models
- Illustrating implications of misaligned causal questions and statistics in settings with competing events and interest in treatment mechanisms
- Randomized interventional effects in semicompeting risks, with application to a hematopoietic cell transplantation study
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