Dynamic activation model for a glutamatergic neurovascular unit

DOI10.1016/J.JTBI.2010.12.007MaRDI QIDQ5963474zbMATH OpenOpenAlexWikidataFDO

Authors Daniela Calvetti, Erkki Somersalo

Publication date 22 February 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2010.12.007

zbMATH Keywords

astrocyteBayesian flux balance analysisbrain energy metabolismglutamatergic neuronneurovascular connection

Mathematics Subject Classification ID

Neural biology (92C20) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Bayesian stationary state flux balance analysis for a skeletal muscle metabolic model
• Large‐Scale Inverse Problems and Quantification of Uncertainty
• Large‐Scale Statistical Parameter Estimation in Complex Systems with an Application to Metabolic Models
• Mathematical physiology. II: Systems physiology
• Sampling-Based Analysis of a Spatially Distributed Model for Liver Metabolism at Steady State

Cited in

(12)

• A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen
• Modeling of slow glutamate diffusion and AMPA receptor activation in the cerebellar glomerulus
• Metabolism plays a central role in the cortical spreading depression: evidence from a mathematical model
• Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: evidence from an integrated computational model
• A bidirectional model for communication in the neurovascular unit
• A spatially distributed computational model of brain cellular metabolism
• Uncertainty quantification in flux balance analysis of spatially lumped and distributed models of neuron-astrocyte metabolism
• A model of indispensability of a large glial layer in cerebrovascular circulation
• Modeling secondary messenger pathways in neurovascular coupling
• A theoretical study on the role of astrocytic activity in neuronal hyperexcitability by a novel neuron-glia mass model
• A spatially distributed model of brain metabolism highlights the role of diffusion in brain energy metabolism
• A model of neurovascular coupling and its application to cortical spreading depolarization

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