Computational aspects of DNA mixture analysis

DOI10.1007/S11222-014-9451-7zbMATH Open1331.92009DBLPjournals/sac/GraversenL15arXiv1307.4956OpenAlexW3124157763WikidataQ54007220 ScholiaQ54007220MaRDI QIDQ5963727FDOQ5963727

Authors: Therese Graversen, Steffen Lauritzen 

Publication date: 23 February 2016

Published in: Statistics and Computing (Search for Journal in Brave)

Abstract: Statistical analysis of DNA mixtures is known to pose computational challenges due to the enormous state space of possible DNA profiles. We propose a Bayesian network representation for genotypes, allowing computations to be performed locally involving only a few alleles at each step. In addition, we describe a general method for computing the expectation of a product of discrete random variables using auxiliary variables and probability propagation in a Bayesian network, which in combination with the genotype network allows efficient computation of the likelihood function and various other quantities relevant to the inference. Lastly, we introduce a set of diagnostic tools for assessing the adequacy of the model for describing a particular dataset.

Full work available at URL: https://arxiv.org/abs/1307.4956

Recommendations

• Statistical analysis of forensic DNA: computational problems solved and to be solved
• Probabilistic expert systems for DNA mixture profiling
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zbMATH Keywords

Bayesian networkdeconvolutiontriangulationmodel diagnosticsjunction treegenotype representationprequential monitor

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10) Image analysis in multivariate analysis (62H35) Computational methods for problems pertaining to biology (92-08)

Cites Work

• Probabilistic Networks and Expert Systems
• Computing the Minimum Fill-In is NP-Complete
• Optimal decoding of linear codes for minimizing symbol error rate (Corresp.)
• Probabilistic Expert Systems for Forensic Inference from Genetic Markers
• On Testing the Validity of Sequential Probability Forecasts
• Sensitivity of inferences in forensic genetics to assumptions about founding genes
• Weight‐of‐evidence for Forensic DNA Profiles
• Probabilistic expert systems for DNA mixture profiling
• Estimation of parameters in DNA mixture analysis

Cited In (10)

• Classification studies based on a spectral representation of DNA
• BAYESIAN NETWORKS IN EDUCATIONAL TESTING
• An integrated software tool for detecting criminals using DNA databases
• Comparison of different methods to analyze a DNA computing library using the polymerase chain reaction
• DNA Computing
• The multivariate Dirichlet-multinomial distribution and its application in forensic genetics to adjust for subpopulation effects using the \(\theta\)-correction
• Probabilistic expert systems for DNA mixture profiling
• A mathematical approach to the analysis of multiplex DNA profiles
• Statistical DNA Forensics
• Interpreting DNA mixtures within a Bayesian framework

Uses Software

• numDeriv
• HUGIN
• Rsolnp
• RHugin
• DNAmixtures

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