Computational aspects of DNA mixture analysis

DOI10.1007/S11222-014-9451-7MaRDI QIDQ5963727zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Therese Graversen, Steffen Lauritzen

Publication date 23 February 2016

Published in Statistics and Computing (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1307.4956

zbMATH Keywords

Bayesian networkdeconvolutiontriangulationmodel diagnosticsjunction treegenotype representationprequential monitor

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10) Image analysis in multivariate analysis (62H35) Computational methods for problems pertaining to biology (92-08)

Abstract: Statistical analysis of DNA mixtures is known to pose computational challenges due to the enormous state space of possible DNA profiles. We propose a Bayesian network representation for genotypes, allowing computations to be performed locally involving only a few alleles at each step. In addition, we describe a general method for computing the expectation of a product of discrete random variables using auxiliary variables and probability propagation in a Bayesian network, which in combination with the genotype network allows efficient computation of the likelihood function and various other quantities relevant to the inference. Lastly, we introduce a set of diagnostic tools for assessing the adequacy of the model for describing a particular dataset.

Recommendations

• Statistical analysis of forensic DNA: computational problems solved and to be solved
• Probabilistic expert systems for DNA mixture profiling
• Statistical DNA Forensics
• Estimation of parameters in DNA mixture analysis
• Interpreting DNA mixtures within a Bayesian framework

Cites work

• Computing the Minimum Fill-In is NP-Complete
• Estimation of parameters in DNA mixture analysis
• On Testing the Validity of Sequential Probability Forecasts
• Optimal decoding of linear codes for minimizing symbol error rate (Corresp.)
• Probabilistic Expert Systems for Forensic Inference from Genetic Markers
• Probabilistic Networks and Expert Systems
• Probabilistic expert systems for DNA mixture profiling
• Sensitivity of inferences in forensic genetics to assumptions about founding genes
• Weight‐of‐evidence for Forensic DNA Profiles

Cited in

(14)

• An integrated software tool for detecting criminals using DNA databases
• Identifying individuals in a complex mixture of DNA with unknown ancestry
• Statistical DNA Forensics
• BAYESIAN NETWORKS IN EDUCATIONAL TESTING
• Classification studies based on a spectral representation of DNA
• An improvement of likelihood ratio in interpreting DNA mixture considering peak area
• The multivariate Dirichlet-multinomial distribution and its application in forensic genetics to adjust for subpopulation effects using the \(\theta\)-correction
• Statistical analysis of forensic DNA: computational problems solved and to be solved
• DNA Computing
• A Bayesian framework for molecular strain identification from mixed diagnostic samples
• Interpreting DNA mixtures within a Bayesian framework
• Probabilistic expert systems for DNA mixture profiling
• A mathematical approach to the analysis of multiplex DNA profiles
• Comparison of different methods to analyze a DNA computing library using the polymerase chain reaction

Describes a project that uses

Uses Software

• numDeriv
• HUGIN
• Rsolnp
• RHugin
• DNAmixtures

This page was built for publication: Computational aspects of DNA mixture analysis

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5963727)