Accumulation Time of Diffusion in a 3D Singularly Perturbed Domain

DOI10.1137/22M1475843MaRDI QIDQ6045348zbMATH OpenOpenAlexFDO

Authors Paul C. Bressloff

Publication date 26 May 2023

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2202.00585

zbMATH Keywords

accumulation timediffusionmatched asymptoticssingularly perturbed domains

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Asymptotic expansions of solutions to PDEs (35C20) Green's functions for elliptic equations (35J08) Initial-boundary value problems for second-order parabolic equations (35K20) Biophysics (92C05)

Abstract: Boundary value problems for diffusion in singularly perturbed domains (domains with small holes removed from the interior) is a topic of considerable current interest. Applications include intracellular diffusive transport and the spread of pollutants or heat from localized sources. In a previous paper, we introduced a new method for characterizing the approach to steady-state in the case of two-dimensional (2D) diffusion. This was based on a local measure of the relaxation rate known as the accumulation time $T(x)$. The latter was calculated by solving the diffusion equation in Laplace space using a combination of matched asymptotics and Green's function methods. We thus obtained an asymptotic expansion of $T(x)$ in powers of $u=-1/lnepsilon$, where $epsilon$ specifies the relative size of the holes. In this paper, we develop the corresponding theory for three-dimensional (3D) diffusion. The analysis is a non-trivial extension of the 2D case due to differences in the singular nature of the Laplace transformed Green's function. In particular, the asymptotic expansion of the solution of the 3D diffusion equation in Laplace space involves terms of order $O((epsilon/s{)}^n)$, where $s$ is the Laplace variable. These $s$-singularities have to be removed by partial series resummations in order to obtain an asymptotic expansion of $T(x)$ in powers of $epsilon$.

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Cites work

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Cited in

(3)

• scientific article; zbMATH DE number 2101455 (Why is no real title available?)
• Characteristic times in a three scale model with overlapping domain decomposition
• Cellular diffusion processes in singularly perturbed domains

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