Operating characteristics of the rank‐based inverse normal transformation for quantitative trait analysis in genome‐wide association studies

DOI10.1111/BIOM.13214MaRDI QIDQ6047769zbMATH OpenOpenAlexWikidataFDO

Authors Susan Redline, Xihong Lin

Publication date 9 October 2023

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/biom.13214

zbMATH Keywords

direct and indirect rank-based inverse normal transformationnonnormalityomnibus testquantitative traitstransformationtype I error rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• A robust distribution-free test for genetic association studies of quantitative traits
• Empirical likelihood-based robust tests for genetic association analysis with quantitative traits
• Integrated quantile rank test (iQRAT) for gene-level associations
• Methods for testing association between uncertain genotypes and quantitative traits
• Association analysis of rare variants with quantitative trait based on minimum \(p\)-value

Cites work

• Applied Regression Analysis
• Approximation Theorems of Mathematical Statistics
• Asymptotic Statistics
• Cauchy Combination Test: A Powerful Test With Analytic p-Value Calculation Under Arbitrary Dependency Structures
• scientific article; zbMATH DE number 1249686 (Why is no real title available?)
• Use of Ranks in One-Criterion Variance Analysis

Cited in

(8)

• A robust distribution-free test for genetic association studies of quantitative traits
• The Cauchy Combination Test under Arbitrary Dependence Structures
• A ROC-based test for evaluating the group difference with an application to neonatal audiology screening
• The development of inverse normal transformations: a review
• Testing for association between ordinal traits and genetic variants in pedigree-structured samples by collapsing and kernel methods
• A Powerful Transformation of Quantitative Responses for Biobank-Scale Association Studies
• Ensemble testing for high-dimensional multiple response models
• Domain-aware matrix completion for phenotype imputation using electronic health record data with applications in genomic research

This page was built for publication: Operating characteristics of the rank‐based inverse normal transformation for quantitative trait analysis in genome‐wide association studies

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6047769)