Discussion on “Adaptive enrichment designs with a continuous biomarker” by Nigel Stallard

DOI10.1111/BIOM.13641MaRDI QIDQ6055893zbMATH OpenOpenAlexFDO

Authors Nancy Flournoy, Sergey Tarima

Publication date 30 October 2023

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/biom.13641

zbMATH Keywords

likelihood estimationthreshold selectionadaptive likelihood ratio testsinformative adaptation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Adaptive enrichment designs with a continuous biomarker
• A signature enrichment design with Bayesian adaptive randomization
• Inference for a two-stage enrichment design
• Biomarker-driven adaptive design
• Bayesian adaptive trial design for a continuous biomarker with possibly nonlinear or nonmonotone prognostic or predictive effects

Cites work

• Asymptotic properties of maximum likelihood estimators with sample size recalculation
• Evaluation of Experiments with Adaptive Interim Analyses
• Sequential analysis. Tests and confidence intervals
• Statistical Applications of the Multivariate Skew Normal Distribution

Cited in

(4)

• Adaptive enrichment designs with a continuous biomarker
• Bayesian adaptive trial design for a continuous biomarker with possibly nonlinear or nonmonotone prognostic or predictive effects
• New insights into adaptive enrichment designs
• Inference for a two-stage enrichment design

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