Mixed‐effects models for health care longitudinal data with an informative visiting process: A Monte Carlo simulation study

DOI10.1111/STAN.12188arXiv1808.00419OpenAlexW3100071030WikidataQ92365767 ScholiaQ92365767MaRDI QIDQ6067656FDOQ6067656

Authors: Alessandro M. Gasparini, Keith Abrams, Jessica K. Barrett, Michael J. Sweeting, Michael J. Crowther 

Publication date: 14 December 2023

Published in: Statistica Neerlandica (Search for Journal in Brave)

Abstract: Electronic health records are being increasingly used in medical research to answer more relevant and detailed clinical questions; however, they pose new and significant methodological challenges. For instance, observation times are likely correlated with the underlying disease severity: patients with worse conditions utilise health care more and may have worse biomarker values recorded. Traditional methods for analysing longitudinal data assume independence between observation times and disease severity; yet, with healthcare data such assumptions unlikely holds. Through Monte Carlo simulation, we compare different analytical approaches proposed to account for an informative visiting process to assess whether they lead to unbiased results. Furthermore, we formalise a joint model for the observation process and the longitudinal outcome within an extended joint modelling framework. We illustrate our results using data from a pragmatic trial on enhanced care for individuals with chronic kidney disease, and we introduce user-friendly software that can be used to fit the joint model for the observation process and a longitudinal outcome.

Full work available at URL: https://arxiv.org/abs/1808.00419

Recommendations

• Joint analysis of longitudinal data and competing terminal events in the presence of dependent observation times with application to chronic kidney disease
• Recurrent Events Analysis With Data Collected at Informative Clinical Visits in Electronic Health Records
• Bayesian latent multi‐state modeling for nonequidistant longitudinal electronic health records
• Joint analysis of longitudinal data with additive mixed effect model for informative observation times
• Weighted regression analysis to correct for informative monitoring times and confounders in longitudinal studies

zbMATH Keywords

longitudinal dataselection biasMonte Carlo simulationmixed-effects modelselectronic health recordsinformative visiting processinverse intensity of visiting weightingrecurrent-events models

Mathematics Subject Classification ID

Statistics (62-XX) Applications of statistics (62Pxx) Linear inference, regression (62Jxx)

Cites Work

• Joint models for longitudinal and time-to-event data. With applications in R
• Estimation and Comparison of Changes in the Presence of Informative Right Censoring by Modeling the Censoring Process
• Analysis of Semiparametric Regression Models for Repeated Outcomes in the Presence of Missing Data
• Cox's regression model for counting processes: A large sample study
• Longitudinal data with follow-up truncated by death: match the analysis method to research aims
• Analysis of Longitudinal Data in the Presence of Informative Observational Times and a Dependent Terminal Event, with Application to Medical Cost Data
• Biased and unbiased estimation in longitudinal studies with informative visit processes
• Longitudinal data analysis for generalized linear models with follow-up dependent on outcome-related variables

Cited In (4)

• Handling of uncertainty in medical data using machine learning and probability theory techniques: a review of 30 years (1991--2020)
• Causal inference with longitudinal data subject to irregular assessment times
• Markov-modulated marked Poisson processes for modeling disease dynamics based on medical claims data
• Quantifying the extent of visit irregularity in longitudinal data

This page was built for publication: Mixed‐effects models for health care longitudinal data with an informative visiting process: A Monte Carlo simulation study

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6067656)