Mendelian Randomization Test of Causal Effect Using High-Dimensional Summary Data

DOI10.5705/SS.202021.0164MaRDI QIDQ6069873zbMATH OpenFDO

Authors Lu Deng, William Wheeler, Kai Yu

Publication date 17 November 2023

Published in STATISTICA SINICA (Search for Journal in Brave)

Full work available at URL https://doi.org/10.5705/SS.202021.0164

zbMATH Keywords

genome-wide association studiesinstrumental variablesMendelian randomizationpleiotropic effectsummary statistics

Mathematics Subject Classification ID

Statistics (62-XX)

Cites work

• Confidence intervals for causal effects with invalid instruments by using two-stage hard thresholding with voting
• Higher criticism for detecting sparse heterogeneous mixtures.
• scientific article; zbMATH DE number 741240 (Why is no real title available?)
• Mendelian randomization as an instrumental variable approach to causal inference
• Mixing: Properties and examples
• On the use of the Lasso for instrumental variables estimation with some invalid instruments
• Pivotal Statistics for Testing Structural Parameters in Instrumental Variables Regression
• Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score
• Tests alternative to higher criticism for high-dimensional means under sparsity and column-wise dependence
• Two robust tools for inference about causal effects with invalid instruments

Cited in

(1)

• Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies

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