Nonparametric analysis of nonhomogeneous multistate processes with clustered observations
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Publication:6074498
DOI10.1111/BIOM.13327zbMATH Open1520.62130arXiv1912.00487OpenAlexW3042109704WikidataQ97516826 ScholiaQ97516826MaRDI QIDQ6074498FDOQ6074498
Authors: Giorgos Bakoyannis 
Publication date: 12 October 2023
Published in: Biometrics (Search for Journal in Brave)
Abstract: Frequently, clinical trials and observational studies involve complex event history data with multiple events. When the observations are independent, the analysis of such studies can be based on standard methods for multi-state models. However, the independence assumption is often violated, such as in multicenter studies, which makes the use of standard methods improper. In this work we address the issue of nonparametric estimation and two-sample testing for the population-averaged transition and state occupation probabilities under general multi-state models based on right-censored, left-truncated, and clustered observations. The proposed methods do not impose assumptions regarding the within-cluster dependence, allow for informative cluster size, and are applicable to both Markov and non-Markov processes. Using empirical process theory, the estimators are shown to be uniformly consistent and to converge weakly to tight Gaussian processes. Closed-form variance estimators are derived, rigorous methodology for the calculation of simultaneous confidence bands is proposed, and the asymptotic properties of the nonparametric tests are established. Furthermore, we provide theoretical arguments for the validity of the nonparametric cluster bootstrap, which can be readily implemented in practice regardless of how complex the underlying multi-state model is. Simulation studies show that the performance of the proposed methods is good, and that methods that ignore the within-cluster dependence can lead to invalid inferences. Finally, the methods are applied to data from a multicenter randomized controlled trial.
Full work available at URL: https://arxiv.org/abs/1912.00487
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Cited In (6)
- Robust inference for event probabilities with non-Markov event data
- Title not available (Why is that?)
- Nonparametric Tests for Continuous Covariate Effects with Multistate Survival Data
- Adjusting for informative cluster size in pseudo-value-based regression approaches with clustered time to event data
- Nonparametric tests for multistate processes with clustered data
- Non‐parametric regression in clustered multistate current status data with informative cluster size
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