Cox regression analysis for distorted covariates with an unknown distortion function

DOI10.1002/BIMJ.202000209MaRDI QIDQ6091677zbMATH OpenOpenAlexFDO

Authors Yanyan Liu, Yuan Shan Wu, Jing Zhang, Haibo Zhou

Publication date 27 November 2023

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2006.01507, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691206

zbMATH Keywords

covariate adjustmentCox regression modeldistorting functionestimated maximum likelihood methodmultiplicative effect

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: We study inference for censored survival data where some covariates are distorted by some unknown functions of an observable confounding variable in a multiplicative form. Example of this kind of data in medical studies is the common practice to normalizing some important observed exposure variables by patients' body mass index (BMI), weight or age. Such phenomenon also appears frequently in environmental studies where ambient measure is used for normalization, and in genomic studies where library size needs to be normalized for next generation sequencing data. We propose a new covariate-adjusted Cox proportional hazards regression model and utilize the kernel smoothing method to estimate the distorting function, then employ an estimated maximum likelihood method to derive estimator for the regression parameters. We establish the large sample properties of the proposed estimator. Extensive simulation studies demonstrate that the proposed estimator performs well in correcting the bias arising from distortion. A real data set from the National Wilms' Tumor Study (NWTS) is used to illustrate the proposed approach.

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Cited in

(2)

• Case-cohort and inference for the proportional hazards model with covariate adjustment
• Research on improved estimation method of the Cox model with contaminated covariable and auxiliary survival information

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