Computational modeling to determine the effect of phenotypic heterogeneity in tumors on the collective tumor-immune interactions

DOI10.1007/s11538-023-01158-zzbMath1519.92107OpenAlexW4368342844MaRDI QIDQ6110454

Kaiqun Wang, Hui Yuan Yang, Di Huang, Yaoyao Du, Guanjie Jia, Yu-Juan Zhang, Wei-Yi Chen, Yanhu Shan

Publication date: 6 July 2023

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-023-01158-z

zbMATH Keywords

multi-scale modelproliferating tumor cellsapoptosis of tumor cellsquiescent tumor cellsT cell inactivationtemporal-spatial distribution

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Medical applications (general) (92C50) Cell biology (92C37)

Cites Work

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• Spatial tumor-immune modeling
• A mathematical model of tumor-immune interactions
• A computational model for investigating tumor apoptosis induced by mesenchymal stem cell-derived secretome
• A novel mathematical model of heterogeneous cell proliferation
• A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD\(8^+\) T cell immune response
• Multiscale Developments of the Cellular Potts Model
• A model of tumor‐immune system interactions with healthy cells and immunotherapies

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