Mapping the Genetic-Imaging-Clinical Pathway with Applications to Alzheimer’s Disease
From MaRDI portal
(Redirected from Publication:6110690)
Abstract: Alzheimer's disease is a progressive form of dementia that results in problems with memory, thinking, and behavior. It often starts with abnormal aggregation and deposition of beta amyloid and tau, followed by neuronal damage such as atrophy of the hippocampi, leading to Alzheimer's Disease (AD). The aim of this paper is to map the genetic-imaging-clinical pathway for AD in order to delineate the genetically regulated brain changes that drive disease progression based on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. We develop a novel two-step approach to delineate the association between high-dimensional 2D hippocampal surface exposures and the Alzheimer's Disease Assessment Scale (ADAS) cognitive score, while taking into account the ultra-high dimensional clinical and genetic covariates at baseline. Analysis results suggest that the radial distance of each pixel of both hippocampi is negatively associated with the severity of behavioral deficits conditional on observed clinical and genetic covariates. These associations are stronger in Cornu Ammonis region 1 (CA1) and subiculum subregions compared to Cornu Ammonis region 2 (CA2) and Cornu Ammonis region 3 (CA3) subregions.
Recommendations
- Bayesian modeling of multiple structural connectivity networks during the progression of Alzheimer's disease
- Identifying Brain Hierarchical Structures Associated with Alzheimer's Disease Using a Regularized Regression Method with Tree Predictors
- Dynamic analysis of synaptic loss and synaptic compensation in the process of associative memory ability decline in Alzheimer's disease
- Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging
- The interplay of biochemical and biomechanical degeneration in Alzheimer's disease
Cites work
- Analysis of secondary phenotypes in multigroup association studies
- Discussion of “Data-driven confounder selection via Markov and Bayesian networks” by Häggström
- Interaction screening for ultrahigh-dimensional data
- L2RM: Low-Rank Linear Regression Models for High-Dimensional Matrix Responses
- Outcome-adaptive Lasso: variable selection for causal inference
- Regularization methods for high-dimensional instrumental variables regression with an application to genetical genomics
- Regularized Matrix Regression
- Sure independence screening for ultrahigh dimensional feature space. With discussion and authors' reply
- Ultra-High Dimensional Variable Selection for Doubly Robust Causal Inference
Cited in
(15)- Computational studies on Alzheimer's disease associated pathways and regulatory patterns using microarray gene expression and network data: revealed association with aging and other diseases
- Data-driven biomarker analysis using computational omics approaches to assess neurodegenerative disease progression
- Decision trees for the analysis of genes involved in Alzheimer's disease pathology
- scientific article; zbMATH DE number 2018193 (Why is no real title available?)
- A Nelson-Aalen Estimate of the Incidence Rates of Early-Onset Alzheimer's Disease Associated with the Presenilin-1 Gene
- Genetics, Alzheimer’s Disease, and Long-Term Care Insurance
- Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging
- Identifying Brain Hierarchical Structures Associated with Alzheimer's Disease Using a Regularized Regression Method with Tree Predictors
- Nonparametric quantile scalar-on-image regression
- Causal mediation analysis with a three-dimensional image mediator
- An integrative network-based mediation model (NMM) to estimate multiple genetic effects on outcomes mediated by functional connectivity
- Low-rank latent matrix-factor prediction modeling for generalized high-dimensional matrix-variate regression
- Sparse functional varying-coefficient mixture regression
- Nuclear norm regularization
- A general framework of brain region detection and genetic variants selection in imaging genetics
This page was built for publication: Mapping the Genetic-Imaging-Clinical Pathway with Applications to Alzheimer’s Disease
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6110690)
