A fusion learning method to subgroup analysis of Alzheimer's disease
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Publication:6134412
Abstract: Uncovering the heterogeneity in the disease progression of Alzheimer's is a key factor to disease understanding and treatment development, so that interventions can be tailored to target the subgroups that will benefit most from the treatment, which is an important goal of precision medicine. However, in practice, one top methodological challenge hindering the heterogeneity investigation is that the true subgroup membership of each individual is often unknown. In this article, we aim to identify latent subgroups of individuals who share a common disorder progress over time, to predict latent subgroup memberships, and to estimate and infer the heterogeneous trajectories among the subgroups. To achieve these goals, we apply a concave fusion learning method proposed in Ma and Huang (2017) and Ma et al. (2019) to conduct subgroup analysis for longitudinal trajectories of the Alzheimer's disease data. The heterogeneous trajectories are represented by subject-specific unknown functions which are approximated by B-splines. The concave fusion method can simultaneously estimate the spline coefficients and merge them together for the subjects belonging to the same subgroup to automatically identify subgroups and recover the heterogeneous trajectories. The resulting estimator of the disease trajectory of each subgroup is supported by an asymptotic distribution. It provides a sound theoretical basis for further conducting statistical inference in subgroup analysis..
Cites work
- scientific article; zbMATH DE number 845714 (Why is no real title available?)
- scientific article; zbMATH DE number 3429948 (Why is no real title available?)
- scientific article; zbMATH DE number 2222296 (Why is no real title available?)
- A plug-in the number of knots selector for polynomial spline regression
- A practical guide to splines.
- Additive regression splines with irrelevant categorical and continuous regressors
- Algorithm AS 136: A K-Means Clustering Algorithm
- Clustering of time-course gene expression data using functional data analysis
- Distributed optimization and statistical learning via the alternating direction method of multipliers
- Efficient Estimation in Marginal Partially Linear Models for Longitudinal/Clustered Data Using Splines
- Efficient Semiparametric Marginal Estimation for Longitudinal/Clustered Data
- Empirical likelihood methods with weakly dependent processes
- Estimation and variable selection for generalized additive partial linear models
- Functional Coefficient Regression Models for Non-linear Time Series: A Polynomial Spline Approach
- Functional-Coefficient Regression Models for Nonlinear Time Series
- Inference for single-index quantile regression models with profile optimization
- Information theoretic measures for clusterings comparison: variants, properties, normalization and correction for chance
- Longitudinal data analysis using generalized linear models
- Model-Based Clustering, Discriminant Analysis, and Density Estimation
- Model-based classification using latent Gaussian mixture models
- Nearly unbiased variable selection under minimax concave penalty
- On the Strong Mixing Property for Linear Sequences
- On the asymptotics of marginal regression splines with longitudinal data
- Simultaneous variable selection and estimation in semiparametric modeling of longitudinal/clustered data
- Sparse varying coefficient models for longitudinal data
- Spline-backfitted kernel smoothing of additive coefficient model
- Tuning parameter selectors for the smoothly clipped absolute deviation method
- Two-step spline estimating equations for generalized additive partially linear models with large cluster sizes
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