Pairwise nonlinear dependence analysis of genomic data

DOI10.1214/23-AOAS1745arXiv2202.09880OpenAlexW4388054937MaRDI QIDQ6138614FDOQ6138614

Authors: Siqi Xiang, Wan Zhang, Siyao Liu, Katherine A. Hoadley, Charles M. Perou, Kai Zhang, J. S. Marron 

Publication date: 16 January 2024

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: In The Cancer Genome Atlas (TCGA) data set, there are many interesting nonlinear dependencies between pairs of genes that reveal important relationships and subtypes of cancer. Such genomic data analysis requires a rapid, powerful and interpretable detection process, especially in a high-dimensional environment. We study the nonlinear patterns among the expression of pairs of genes from TCGA using a powerful tool called Binary Expansion Testing. We find many nonlinear patterns, some of which are driven by known cancer subtypes, some of which are novel.

Full work available at URL: https://arxiv.org/abs/2202.09880

zbMATH Keywords

nonlinear dependencebinary expansionGenomic datanonparametric dependence testing

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

Cites Work

• Measuring and testing dependence by correlation of distances
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• BET on Independence
• A Non-Parametric Test of Independence
• Energy statistics: a class of statistics based on distances

Cited In (2)

• A new set of tools for goodness-of-fit validation
• ODC and ROC curves, comparison curves and stochastic dominance

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