Pairwise nonlinear dependence analysis of genomic data

DOI10.1214/23-AOAS1745MaRDI QIDQ6138614zbMATH OpenOpenAlexFDO

Authors Siqi Xiang, Wan Zhang, Siyao Liu, Katherine A. Hoadley, Charles M. Perou, Kai Zhang, J. S. Marron

Publication date 16 January 2024

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2202.09880

zbMATH Keywords

nonlinear dependencebinary expansionGenomic datanonparametric dependence testing

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

Abstract: In The Cancer Genome Atlas (TCGA) data set, there are many interesting nonlinear dependencies between pairs of genes that reveal important relationships and subtypes of cancer. Such genomic data analysis requires a rapid, powerful and interpretable detection process, especially in a high-dimensional environment. We study the nonlinear patterns among the expression of pairs of genes from TCGA using a powerful tool called Binary Expansion Testing. We find many nonlinear patterns, some of which are driven by known cancer subtypes, some of which are novel.

Cites work

• A Non-Parametric Test of Independence
• BET on independence
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Cited in

(2)

• A new set of tools for goodness-of-fit validation
• ODC and ROC curves, comparison curves and stochastic dominance

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