Neuronal Resilience and Calcium Signaling Pathways in the Context of Synapse Loss and Calcium Leaks: A Computational Modeling Study and Implications for Alzheimer’s Disease

DOI10.1137/23M1557842zbMATH Open1530.92037OpenAlexW4389339930MaRDI QIDQ6139400FDOQ6139400

Authors: James Rosado, Gillian Queisser 

Publication date: 18 December 2023

Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1137/23m1557842

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zbMATH Keywords

Alzheimer's diseaseamyloid-betanumerical analysismultiscale modelingsynapse losselectro-calcium model

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20) Computational methods for problems pertaining to biology (92-08) Pathology, pathophysiology (92C32)

Cites Work

• Title not available (Why is that?)
• Models of calcium signalling
• High order semi-implicit multistep methods for time-dependent partial differential equations
• Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons
• What is required for neuronal calcium waves? A numerical parameter study
• Unconditional stability for multistep ImEx schemes: practice
• The progression towards Alzheimer's disease described as a bistable switch arising from the positive loop between amyloids and \(\mathrm{Ca}^{2+}\)

Cited In (1)

• Inferring parameters of pyramidal neuron excitability in mouse models of Alzheimer's disease using biophysical modeling and deep learning

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