Neuronal Resilience and Calcium Signaling Pathways in the Context of Synapse Loss and Calcium Leaks: A Computational Modeling Study and Implications for Alzheimer’s Disease

DOI10.1137/23M1557842MaRDI QIDQ6139400zbMATH OpenOpenAlexFDO

Authors James Rosado, Gillian Queisser

Publication date 18 December 2023

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1137/23m1557842

zbMATH Keywords

Alzheimer's diseaseamyloid-betanumerical analysismultiscale modelingsynapse losselectro-calcium model

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20) Computational methods for problems pertaining to biology (92-08) Pathology, pathophysiology (92C32)

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Cites work

• scientific article; zbMATH DE number 5180707 (Why is no real title available?)
• High order semi-implicit multistep methods for time-dependent partial differential equations
• Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons
• Models of calcium signalling
• The progression towards Alzheimer's disease described as a bistable switch arising from the positive loop between amyloids and \(\mathrm{Ca}^{2+}\)
• Unconditional stability for multistep ImEx schemes: practice
• What is required for neuronal calcium waves? A numerical parameter study

Cited in

(1)

• Inferring parameters of pyramidal neuron excitability in mouse models of Alzheimer's disease using biophysical modeling and deep learning

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