Quality of approximating a mass-emitting object by a point source in a diffusion model

DOI10.1016/J.CAMWA.2023.10.034MaRDI QIDQ6143687zbMATH OpenOpenAlexFDO

Authors Q. Peng, Sander Hille

Publication date 5 January 2024

Published in Computers & Mathematics with Applications (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2305.00717

zbMATH Keywords

diffusion equationDirac Delta distributionGaussian kernelnumerical analysispoint source

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Abstract: For the sake of computational efficiency and for theoretical purposes, in mathematical modelling, the Dirac Delta distributions are often utilized as a replacement for cells or vesicles, since the size of cells or vesicles is much smaller than the size of the surrounding tissues. Here, we consider the scenario that the cell or the vesicle releases the diffusive compounds to the immediate environment, which is modelled by the diffusion equation. Typically, one separates the intracellular and extracellular environment and uses homogeneous Neumann boundary condition for the cell boundary (so-called spatial exclusion approach), while the point source approach neglects the intracellular environment. We show that extra conditions are needed such that the solutions to the two approaches are consistent. We prove a necessary and sufficient condition for the consistency. Suggested by the numerical results, we conclude that an initial condition in the form of Gaussian kernel in the point source approach compensates for a time-delay discrepancy between the solutions to the two approaches in the numerical solutions. Various approaches determining optimal amplitude and variance of the Gaussian kernel have been discussed.

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Cites work

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Cited in

(5)

• scientific article; zbMATH DE number 5288629 (Why is no real title available?)
• Using multiple Dirac delta points to describe inhomogeneous flux density over a cell boundary in a single-cell diffusion model
• Approximating a spatially-heterogeneously mass-emitting object by multiple point sources in a diffusion model
• Positivity and long-term behaviour of a diffusion model with measure-valued nonlocal reaction term: applications in bioscience and engineering
• On the properties of an emission-generating technology and its parametric representation

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