Time‐optimal control of piecewise affine bistable gene‐regulatory networks

DOI10.1002/RNC.6012MaRDI QIDQ6152809zbMATH OpenOpenAlexFDO

Authors Nicolas Augier, Agustín Gabriel Yabo

Publication date 13 February 2024

Published in International Journal of Robust and Nonlinear Control (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/rnc.6012

zbMATH Keywords

biological systemshybrid systemsbistable switchgenetic toggle switchhybrid optimal controlgenetic regulatory systems

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Systems biology, networks (92C42) Optimality conditions for solutions belonging to restricted classes (Lipschitz controls, bang-bang controls, etc.) (49K30) Attainable sets, reachability (93B03)

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Cites work

• scientific article; zbMATH DE number 3224758 (Why is no real title available?)
• A mathematical framework for the control of piecewise-affine models of gene networks
• A passivity-based stability criterion for a class of biochemical reaction networks
• Exact control of genetic networks in a qualitative framework: the bistable switch example
• Minimal time trajectories for two-level quantum systems with two bounded controls
• Optimal bacterial resource allocation: metabolite production in continuous bioreactors
• Optimal control of bacterial growth for the maximization of metabolite production
• Passivity gains and the ``secant condition for stability
• Qualitative control of undesired oscillations in a genetic negative feedback loop with uncertain measurements
• The Poincaré-Bendixson theorem for monotone cyclic feedback systems
• The hybrid maximum principle is a consequence of Pontryagin's maximum principle
• The turnpike property in finite-dimensional nonlinear optimal control
• Time minimal trajectories for a spin 1∕2 particle in a magnetic field

Cited in

(2)

• Random periodic sequence of globally mean-square exponentially stable discrete-time stochastic genetic regulatory networks with discrete spatial diffusions
• On L^1 and time-optimal state transitions in piecewise linear models of gene-regulatory networks

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