Existence analysis of a cross-diffusion system with nonlinear Robin boundary conditions for vesicle transport in neurites

DOI10.1016/J.NA.2024.113494MaRDI QIDQ6153610zbMATH OpenOpenAlexWikidataFDO

Authors Markus Fellner, Ansgar Jüngel

Publication date 14 February 2024

Published in Nonlinear Analysis. Theory, Methods \& Applications. Series A: Theory and Methods (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2305.15281

zbMATH Keywords

cross-diffusion equationsexistence analysisneurite growthnonlinear Robin boundary conditionsvesicle transport

Mathematics Subject Classification ID

Initial-boundary value problems for second-order parabolic systems (35K51) Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61) Degenerate parabolic equations (35K65) Neural biology (92C20)

Abstract: A one-dimensional cross-diffusion system modeling the transport of vesicles in neurites is analyzed. The equations are coupled via nonlinear Robin boundary conditions to ordinary differential equations for the number of vesicles in the reservoirs in the cell body and the growth cone at the end of the neurite. The existence of bounded weak solutions is proved by using the boundedness-by-entropy method. Numerical simulations show the dynamical behavior of the concentrations of anterograde and retrograde vesicles in the neurite.

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Cites work

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