Fisher-Pitman Permutation Tests Based on Nonparametric Poisson Mixtures with Application to Single Cell Genomics

DOI10.1080/01621459.2022.2120401arXiv2106.03022OpenAlexW4296142578MaRDI QIDQ6154002FDOQ6154002

Author name not available (Why is that?)

Publication date: 19 March 2024

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Abstract: This paper investigates the theoretical and empirical performance of Fisher-Pitman-type permutation tests for assessing the equality of unknown Poisson mixture distributions. Building on nonparametric maximum likelihood estimators (NPMLEs) of the mixing distribution, these tests are theoretically shown to be able to adapt to complicated unspecified structures of count data and also consistent against their corresponding ANOVA-type alternatives; the latter is a result in parallel to classic claims made by Robinson (Robinson, 1973). The studied methods are then applied to a single-cell RNA-seq data obtained from different cell types from brain samples of autism subjects and healthy controls; empirically, they unveil genes that are differentially expressed between autism and control subjects yet are missed using common tests. For justifying their use, rate optimality of NPMLEs is also established in settings similar to nonparametric Gaussian (Wu and Yang, 2020a) and binomial mixtures (Tian et al., 2017; Vinayak et al., 2019).

Full work available at URL: https://arxiv.org/abs/2106.03022

zbMATH Keywords

nonparametric MLEminimax risksingle-cell genomicsFisher-Pitman permutation testsnonparametric Poisson mixture

Mathematics Subject Classification ID

Statistics (62-XX)

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