Periodic insulin stimulation of Akt: dynamic steady states and robustness

DOI10.1016/J.MBS.2023.109113MaRDI QIDQ6154147zbMATH OpenOpenAlexFDO

Authors Catheryn W. Gray, Adelle C. F. Coster

Publication date 14 February 2024

Published in Mathematical Biosciences (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.mbs.2023.109113

zbMATH Keywords

Akt/PKBinsulin signallingODE modelperiodic stimulationsignalling

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Physiology (general) (92C30)

Recommendations

• From insulin to Akt: time delays and dominant processes
• Selective regulation of the insulin-Akt pathway by simultaneous processing of blood insulin pattern in the liver
• The Akt switch model: is location sufficient?
• Crosstalk in transition: the translocation of Akt
• A molecular mathematical model of glucose mobilization and uptake

Cites work

• A calcium-based phantom bursting model for pancreatic islets
• A model for ultradian oscillations of insulin and glucose
• A molecular mathematical model of glucose mobilization and uptake
• Crosstalk in transition: the translocation of Akt
• Deconstructing the integrated oscillator model for pancreatic -cells
• From insulin to Akt: time delays and dominant processes
• Mathematical investigation of diabetically impaired ultradian oscillations in the glucose-insulin regulation
• Modeling the glucose-insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays
• Transitions between bursting modes in the integrated oscillator model for pancreatic \(\beta\)-cells

This page was built for publication: Periodic insulin stimulation of Akt: dynamic steady states and robustness

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6154147)