Statistical theory of asymmetric damage segregation in clonal cell populations

DOI10.1016/J.MBS.2023.108980MaRDI QIDQ6157781zbMATH OpenFDO

Authors Arkady Pikovsky, Lev S. Tsimring

Publication date 22 June 2023

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2302.08071

zbMATH Keywords

asymmetric damage segregationfractalFrobenius-Perron equationiterated function system

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Cell biology (92C37) Population dynamics (general) (92D25)

Abstract: Asymmetric damage segregation (ADS) is ubiquitous among unicellular organisms: After a mother cell divides, its two daughter cells receive sometimes slightly, sometimes strongly different fractions of damaged proteins accumulated in the mother cell. Previous studies demonstrated that ADS provides a selective advantage over symmetrically dividing cells by rejuvenating and perpetuating the population as a whole. In this work we focus on the statistical properties of damage in individual lineages and the overall damage distributions in growing populations for a variety of ADS models with different rules governing damage accumulation, segregation, and the lifetime dependence on damage. We show that for a large class of deterministic ADS rules the trajectories of damage along the lineages are chaotic, and the distributions of damage in cells born at a given time asymptotically becomes fractal. By exploiting the analogy of linear ADS models with the Iterated Function Systems known in chaos theory, we derive the Frobenius-Perron equation for the stationary damage density distribution and analytically compute the damage distribution moments and fractal dimensions. We also investigate nonlinear and stochastic variants of ADS models and show the robustness of the salient features of the damage distributions.

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Cited in

(2)

• Coarse-grained Shannon entropy of random walks with shrinking steps
• Fusion leads to effective segregation of damage during cell division: an analytical treatment

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