Flexible inference of optimal individualized treatment strategy in covariate adjusted randomization with multiple covariates
From MaRDI portal
(Redirected from Publication:6158220)
Abstract: To maximize clinical benefit, clinicians routinely tailor treatment to the individual characteristics of each patient, where individualized treatment rules are needed and are of significant research interest to statisticians. In the covariate-adjusted randomization clinical trial with many covariates, we model the treatment effect with an unspecified function of a single index of the covariates and leave the baseline response completely arbitrary. We devise a class of estimators to consistently estimate the treatment effect function and its associated index while bypassing the estimation of the baseline response, which is subject to the curse of dimensionality. We further develop inference tools to identify predictive covariates and isolate effective treatment region. The usefulness of the methods is demonstrated in both simulations and a clinical data example.
Cites work
- \({\mathcal Q}\)-learning
- A robust method for estimating optimal treatment regimes
- A simple method for estimating interactions between a treatment and a large number of covariates
- Concordance and value information criteria for optimal treatment decision
- Concordance-assisted learning for estimating optimal individualized treatment regimes
- D-learning to estimate optimal individual treatment rules
- Deep advantage learning for optimal dynamic treatment regime
- Dynamic treatment regimes: technical challenges and applications
- Estimating individualized treatment rules using outcome weighted learning
- Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials
- High-dimensional \(A\)-learning for optimal dynamic treatment regimes
- High-dimensional inference for personalized treatment decision
- Inference for non-regular parameters in optimal dynamic treatment regimes
- Inference for optimal dynamic treatment regimes using an adaptive m-out-of-n bootstrap scheme
- Interpretable dynamic treatment regimes
- On estimation of the optimal treatment regime with the additive hazards model
- Optimal Dynamic Treatment Regimes
- Optimal Estimator for the Survival Distribution and Related Quantities for Treatment Policies in Two‐Stage Randomization Designs in Clinical Trials
- Optimal Structural Nested Models for Optimal Sequential Decisions
- Penalized Q-learning for dynamic treatment regimens
- Performance guarantees for individualized treatment rules
- Q-learning with censored data
- Quasi-oracle estimation of heterogeneous treatment effects
- Regret-Regression for Optimal Dynamic Treatment Regimes
- Reinforcement learning strategies for clinical trials in nonsmall cell lung cancer
- Robust Q-learning
- Root-N-Consistent Semiparametric Regression
- Selecting Therapeutic Strategies Based on Efficacy and Death in Multicourse Clinical Trials
- Semiparametric efficient estimation of survival distributions in two-stage randomisation designs in clinical trials with censored data
- Semiparametric least squares (SLS) and weighted SLS estimation of single-index models
- Semiparametric single-index model for estimating optimal individualized treatment strategy
- Sequential advantage selection for optimal treatment regime
- Using decision lists to construct interpretable and parsimonious treatment regimes
Cited in
(3)
This page was built for publication: Flexible inference of optimal individualized treatment strategy in covariate adjusted randomization with multiple covariates
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6158220)
