Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. Part 2 – Derivation of the macroscopic tridomain model by unfolding homogenization method

DOI10.3233/ASY-221804MaRDI QIDQ6163318zbMATH OpenFDO

Authors Fakhrielddine Bader, Mostafa Bendahmane, Mazen Saad, Raafat Talhouk

Publication date 26 June 2023

Published in Asymptotic Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2209.07169

zbMATH Keywords

cardiac electric fieldgap junctionshomogenization theoryreaction-diffusion systemtime-periodic unfolding methodtridomain model

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Weak solutions to PDEs (35D30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biological applications of optics and electromagnetic theory (78A70) Physiology (general) (92C30) Cell biology (92C37)

Abstract: We study the homogenization of a novel microscopic tridomain system, allowing for a more detailed analysis of the properties of cardiac conduction than the classical bidomain and monodomain models. In (Acta Appl.Math. 179 (2022) 1--35), we detail this model in which gap junctions are considered as the connections between adjacent cells in cardiac muscle and could serve as alternative or supporting pathways for cell-to-cell electrical signal propagation. Departing from this microscopic cellular model, we apply the periodic unfolding method to derive the macroscopic tridomain model. Several difficulties prevent the application of unfolding homogenization results, including the degenerate temporal structure of the tridomain equations and a nonlinear dynamic boundary condition on the cellular membrane. To prove the convergence of the nonlinear terms, especially those defined on the microscopic interface, we use the boundary unfolding operator and a Kolmogorov--Riesz compactness's result.

Recommendations

• Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness
• Three scale unfolding homogenization method applied to cardiac bidomain model
• The Cardiac bidomain model and homogenization
• Unfolding homogenization method applied to physiological and phenomenological bidomain models in electrocardiology
• Mathematical analysis and 2-scale convergence of a heterogeneous microscopic bidomain model

Cites work

• A characterization of relatively compact sets in L^p(, B)
• A hierarchy of models for the electrical conduction in biological tissues via two-scale convergence: the nonlinear case
• Derivation of a new macroscopic bidomain model including three scales for the electrical activity of cardiac tissue
• Effective Transmission Conditions for Reaction-Diffusion Processes in Domains Separated by an Interface
• Homogenization of a diffusion-reaction system with surface exchange and evolving hypersurface
• Homogenization of reaction-diffusion processes in a two-component porous medium with nonlinear flux conditions at the interface
• scientific article; zbMATH DE number 3302617 (Why is no real title available?)
• Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness
• Multiscale Modeling for the Bioelectric Activity of the Heart
• On a hierarchy of models for electrical conduction in biological tissues
• The periodic unfolding method in domains with holes
• The periodic unfolding method. Theory and applications to partial differential problems
• Three scale unfolding homogenization method applied to cardiac bidomain model
• Unfolding homogenization method applied to physiological and phenomenological bidomain models in electrocardiology

Cited in

(8)

• Deriving macroscopic myocardial conductivities by homogenization of microscopic models
• Derivation of a new macroscopic bidomain model including three scales for the electrical activity of cardiac tissue
• Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. I: Modeling and well-posedness
• Unfolding homogenization method applied to physiological and phenomenological bidomain models in electrocardiology
• Derivation of the bidomain equations for a beating heart with a general microstructure
• Mathematical analysis and 2-scale convergence of a heterogeneous microscopic bidomain model
• Convergence Analysis of BDDC Preconditioners for Composite DG Discretizations of the Cardiac Cell-By-Cell Model
• Homogenization of an electrophysiological model for a strand of cardiac myocytes with gap-junctional and electric-field coupling

This page was built for publication: Microscopic tridomain model of electrical activity in the heart with dynamical gap junctions. Part 2 – Derivation of the macroscopic tridomain model by unfolding homogenization method

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6163318)