A diploid population model for copy number variation of genetic elements

DOI10.1214/23-EJP934zbMATH Open1519.92148arXiv2204.11140MaRDI QIDQ6164909FDOQ6164909

Authors: Peter Pfaffelhuber, Anton Wakolbinger 

Publication date: 4 July 2023

Published in: Electronic Journal of Probability (Search for Journal in Brave)

Abstract: We study the following model for a diploid population of constant size $N$: Every individual carries a random number of (genetic) elements. Upon a reproduction event each of the two parents passes each element independently with probability $frac12$ on to the offspring. We study the process $X^N=(X^N(1),X^N(2),\mathrm{...})$, where $X_t^N(k)$ is the frequency of individuals at time $t$ that carry $k$ elements, and prove convergence (in some weak sense) of $X^N$ jointly with its empirical first moment $Z^N$ to the ``slow-fast system $(Z,X)$, where $X_t=extPoi(Z_t)$ and $Z$ evolves according to a critical Feller branching process. We discuss heuristics explaining this finding and some extensions and limitations.

Full work available at URL: https://arxiv.org/abs/2204.11140

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zbMATH Keywords

Poisson approximationslow-fast systemtransposable elementsFeller branching diffusion

Mathematics Subject Classification ID

Problems related to evolution (92D15) Applications of branching processes (60J85) Random measures (60G57)

Cites Work

• Title not available (Why is that?)
• Tightness criteria for laws of semimartingales
• Random time changes and convergence in distribution under the Meyer-Zheng conditions
• Noise-Induced Phenomena in Slow-Fast Dynamical Systems
• On the Poisson equation and diffusion approximation. I
• Title not available (Why is that?)
• Recent common ancestors of all present-day individuals
• Solutions of a stochastic differential equation forced onto a manifold by a large drift
• The distribution of surviving blocks of an ancestral genome
• Chromosome painting: how recombination mixes ancestral colors

Cited In (3)

• A model for Mendelian populations demogenetics
• Slow-fast stochastic diffusion dynamics and quasi-stationarity for diploid populations with varying size
• Loss of genetic variation in the two-locus multiallelic haploid model

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