Numerical modeling of the brain poromechanics by high-order discontinuous Galerkin methods

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Publication:6166563

DOI10.1142/S0218202523500367zbMATH Open1517.65106arXiv2210.02272OpenAlexW4365516420MaRDI QIDQ6166563FDOQ6166563

Luca Dedé, Author name not available (Why is that?), Paola F. Antonietti, Alfio Quarteroni

Publication date: 3 August 2023

Published in: M\(^3\)AS. Mathematical Models \& Methods in Applied Sciences (Search for Journal in Brave)

Abstract: We introduce and analyze a discontinuous Galerkin method for the numerical modelling of the equations of Multiple-Network Poroelastic Theory (MPET) in the dynamic formulation. The MPET model can comprehensively describe functional changes in the brain considering multiple scales of fluids. Concerning the spatial discretization, we employ a high-order discontinuous Galerkin method on polygonal and polyhedral grids and we derive stability and a priori error estimates. The temporal discretization is based on a coupling between a Newmark -method for the momentum equation and a heta-method for the pressure equations. After the presentation of some verification numerical tests, we perform a convergence analysis using an agglomerated mesh of a geometry of a brain slice. Finally we present a simulation in a three dimensional patient-specific brain reconstructed from magnetic resonance images. The model presented in this paper can be regarded as a preliminary attempt to model the perfusion in the brain.


Full work available at URL: https://arxiv.org/abs/2210.02272




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