Local identifiability analysis, parameter subset selection and verification for a minimal brain PBPK model

DOI10.1007/s11538-023-01234-4MaRDI QIDQ6183181

Ralph C. Smith, Mansoor A. Haider, Kamala Dadashova

Publication date: 26 January 2024

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

zbMATH Keywords

identifiabilityenergy statisticslocal sensitivity analysisparameter subset selectionPBPK modeling

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Linear ordinary differential equations and systems (34A30)

Cites Work

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• Modeling and parameter subset selection for fibrin polymerization kinetics with applications to wound healing
• A fast algorithm to assess local structural identifiability
• A sensitivity matrix based methodology for inverse problem formulation
• The complex-step derivative approximation
• Numerical Differentiation of Analytic Functions

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