An optimization based 3D-1D coupling strategy for tissue perfusion and chemical transport during tumor-induced angiogenesis
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3D-1D couplingdomain-decompositionfluid and chemical transport in evolving networksmathematical model of angiogenesisnon conforming meshoptimization methods for PDE problems
PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Developmental biology, pattern formation (92C15) Cell movement (chemotaxis, etc.) (92C17) Pathology, pathophysiology (92C32) Physiological flow (92C35)
Abstract: A new mathematical model and numerical approach are proposed for the simulation of fluid and chemical exchanges between a growing capillary network and the surrounding tissue, in the context of tumor-induced angiogenesis. Thanks to proper modeling assumptions the capillaries are reduced to their centerline: a well posed mathematical model is hence worked out, based on the coupling between a three-dimensional and a one-dimensional equation (3D-1D coupled problem). Also the application of a PDE-constrained optimization formulation is here proposed for the first time for angiogenesis simulations. Under this approach no mesh conformity is required, thus making the method particularly suitable for this kind of application, since no remeshing is required as the capillary network grows. In order to handle both the evolution of the quantities of interest and the changes in the geometry, a discrete-hybrid strategy is adopted, combining a continuous modeling of the tissue and of the chemicals with a discrete tip-tracking model to account for the vascular network growth. The tip-tracking strategy, together with some proper rules for branching and anastomosis, is able to provide a realistic representation of the capillary network.
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- scientific article; zbMATH DE number 4170706 (Why is no real title available?)
- scientific article; zbMATH DE number 484710 (Why is no real title available?)
- scientific article; zbMATH DE number 898086 (Why is no real title available?)
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Cited in
(5)- Modelling and simulation of anisotropic growth in brain tumours through poroelasticity: a study of ventricular compression and therapeutic protocols
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- A 3D-1D virtual element method for modeling root water uptake
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