Ongoing HIV replication in lymph node sanctuary sites in treated individuals contributes to the total latent HIV at a very slow rate

DOI10.1016/j.jtbi.2023.111651OpenAlexW4388007119MaRDI QIDQ6192816

Michael J. Piovoso, Aditya Jagarapu, Ryan Zurakowski, Sasan Paryad-Zanjani

Publication date: 13 February 2024

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2023.111651

zbMATH Keywords

HIVmathematical biologylymph nodeantiretroviralsongoing replication

Mathematics Subject Classification ID

Medical epidemiology (92C60) Pathology, pathophysiology (92C32)

Cites Work

• HIV-1 infection and low steady state viral loads
• Spatial modeling of HIV cryptic viremia and 2-LTR formation during raltegravir intensification
• Model of neurotransmitter fast transport in axon terminal of presynaptic neuron
• Compartment model of neuropeptide synaptic transport with impulse control
• Modeling HIV persistence, the latent reservoir, and viral blips
• Drug concentration heterogeneity facilitates the evolution of drug resistance

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