Average sensitivity of nested canalizing multivalued functions

DOI10.1007/978-3-031-42697-1_10MaRDI QIDQ6199822zbMATH OpenFDO

Authors Elisabeth Remy, Paul Ruet

Publication date 28 February 2024

Published in Computational Methods in Systems Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2211.14649

zbMATH Keywords

multivalued functionsaverage sensitivitynested canalizing functionsregulatory network modelling

Mathematics Subject Classification ID

Systems biology, networks (92C42) Boolean functions (06E30)

Abstract: The canalizing properties of biological functions have been mainly studied in the context of Boolean modelling of gene regulatory networks. An important mathematical consequence of canalization is a low average sensitivity, which ensures in particular the expected robustness to noise. In certain situations, the Boolean description is too crude, and it may be necessary to consider functions involving more than two levels of expression. We investigate here the properties of nested canalization for these multivalued functions. We prove that the average sensitivity of nested canalizing multivalued functions is bounded above by a constant. In doing so, we introduce a generalization of nested canalizing multivalued functions, which we call weakly nested canalizing, for which this upper bound holds.

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Cites work

• Analysis of Boolean Functions
• Boolean functions with low average sensitivity depend on few coordinates
• Boolean nested canalizing functions: a comprehensive analysis
• Dynamical behaviour of biological regulatory networks. II: Immunity control in bacteriophage lambda
• Graphic requirements for multistability and attractive cycles in a Boolean dynamical framework
• Inferring biologically relevant models: nested canalyzing functions
• Local cycles and dynamical properties of Boolean networks
• Multistate nested canalizing functions and their networks
• Regulatory patterns in molecular interaction networks
• The number and probability of canalizing functions
• The number of multistate nested canalyzing functions

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