Average sensitivity of nested canalizing multivalued functions

DOI10.1007/978-3-031-42697-1_10arXiv2211.14649MaRDI QIDQ6199822FDOQ6199822

Authors: Elisabeth Remy, Paul Ruet 

Publication date: 28 February 2024

Published in: Computational Methods in Systems Biology (Search for Journal in Brave)

Abstract: The canalizing properties of biological functions have been mainly studied in the context of Boolean modelling of gene regulatory networks. An important mathematical consequence of canalization is a low average sensitivity, which ensures in particular the expected robustness to noise. In certain situations, the Boolean description is too crude, and it may be necessary to consider functions involving more than two levels of expression. We investigate here the properties of nested canalization for these multivalued functions. We prove that the average sensitivity of nested canalizing multivalued functions is bounded above by a constant. In doing so, we introduce a generalization of nested canalizing multivalued functions, which we call weakly nested canalizing, for which this upper bound holds.

Full work available at URL: https://arxiv.org/abs/2211.14649

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zbMATH Keywords

multivalued functionsaverage sensitivitynested canalizing functionsregulatory network modelling

Mathematics Subject Classification ID

Systems biology, networks (92C42) Boolean functions (06E30)

Cites Work

• Analysis of Boolean Functions
• Graphic requirements for multistability and attractive cycles in a Boolean dynamical framework
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• Boolean nested canalizing functions: a comprehensive analysis
• Dynamical behaviour of biological regulatory networks. II: Immunity control in bacteriophage lambda
• Multistate nested canalizing functions and their networks
• Local cycles and dynamical properties of Boolean networks

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