Traveling waves in a coarse‐grained model of volume‐filling cell invasion: Simulations and comparisons
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Publication:6204635
DOI10.1111/SAPM.12635arXiv2302.11345OpenAlexW4386027948MaRDI QIDQ6204635FDOQ6204635
Ruth E. Baker, Philip K. Maini, T. Lorenzi, Author name not available (Why is that?)
Publication date: 2 April 2024
Published in: Studies in Applied Mathematics (Search for Journal in Brave)
Abstract: Many reaction-diffusion models produce travelling wave solutions that can be interpreted as waves of invasion in biological scenarios such as wound healing or tumour growth. These partial differential equation models have since been adapted to describe the interactions between cells and extracellular matrix (ECM), using a variety of different underlying assumptions. In this work, we derive a system of reaction-diffusion equations, with cross-species density-dependent diffusion, by coarse-graining an agent-based, volume-filling model of cell invasion into ECM. We study the resulting travelling wave solutions both numerically and analytically across various parameter regimes. Subsequently, we perform a systematic comparison between the behaviours observed in this model and those predicted by simpler models in the literature that do not take into account volume-filling effects in the same way. Our study justifies the use of some of these simpler, more analytically tractable models in reproducing the qualitative properties of the solutions in some parameter regimes, but it also reveals some interesting properties arising from the introduction of cell and ECM volume-filling effects, where standard model simplifications might not be appropriate.
Full work available at URL: https://arxiv.org/abs/2302.11345
reaction-diffusiontraveling wavespartial differential equationagent-based modelcontinuum modelvolume-fillingcell invasion
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