Sensitivity analysis of circadian entrainment in the space of phase response curves

DOI10.1007/978-94-017-9047-5_3arXiv1211.7317MaRDI QIDQ6237645FDOQ6237645

Publication date: 30 November 2012

Abstract: Sensitivity analysis is a classical and fundamental tool to evaluate the role of a given parameter in a given system characteristic. Because the phase response curve is a fundamental input--output characteristic of oscillators, we developed a sensitivity analysis for oscillator models in the space of phase response curves. The proposed tool can be applied to high-dimensional oscillator models without facing the curse of dimensionality obstacle associated with numerical exploration of the parameter space. Application of this tool to a state-of-the-art model of circadian rhythms suggests that it can be useful and instrumental to biological investigations.

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